Opioid antagonists, such as naloxone, are precise antidotes to respiratory depression ensuing from opioid overdose. For clinically significant respiratory or circulatory melancholy secondary to acetaminophen and codeine overdose, administer an opioid antagonist. Marked differences could exist in the analgesic effect provided by codeine due to genetic variants in the CYP https://britedirectory.com/listings13181804/promethazine-with-codeine-doses-for-adults-an-overview