Pentobarbital will decrease the level or effect of larotrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. pentobarbital will decrease the level or effect of levoketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of buprenorphine buccal by affecting hepatic/intestinal enzyme... https://e-bookmarks.com/story5976711/pentobarbital-effects-opzioni