Within the LSD-sure crystal construction, the side chain of the lid residue L209EL2 forms in depth hydrophobic contacts with the two LSD and encompassing residues in TMs III, IV, and V (Determine 4C). When the lid moved aside to expose the binding pocket in simulation, several of those contacts broke. https://charlielhctk.estate-blog.com/34223749/the-lsd-crystal-diaries