Pentobarbital decreases amounts of elvitegravir/cobicistat/emtricitabine/tenofovir DF by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Could lead to lack of virologic reaction and possible resistance. pentobarbital will lower the extent or outcome of nelfinavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. pentobarbit... https://homert455fwl4.livebloggs.com/profile