Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts in the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactions, which hap... https://roberto012jjd3.thebindingwiki.com/user