This mechanism might be through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the clinical response to doxycycline ought to be monitored carefully. Phenytoin, sodium valproate, valproic acid: The outcome of barbiturates on the metabolism of phenytoin seems for being variable. https://lillianl776drd1.bloggerswise.com/profile