The known influence of such PTMs on ATXN2’s function and SCA2 pathogenesis stays constrained. In other polyQ ailments, several reports proposed that proteolytic cleavage of polyQ proteins could Perform an essential position in pathogenesis [36, 45]. Aligned with this particular concept, the presence of an enriched forty two kDa fragment within https://erict110kwh4.boyblogguide.com/27858144/l-162-things-to-know-before-you-buy