Esophageal Ailments including noncardiac upper body agony, swallowing Problems, and regurgitation/rumination syndromes are prevalent in medical observe. Virtually all gastroenterologists and medical professionals working with these disorders supply empiric and symptomatic treatment without having an assessment or understanding of the reason for the signs. In a review in this issue https://www.directivepublications.org/journal-of-gastroenterology-hepatology-and-endoscopy-research/