Substitution at R3 with a halogen or alkoxy group (74f–74i) triggered a slight rise in cellular potency with the halide analogs (74g–h) demonstrating optimum the potency during the group. Additional optimization triggered the discovery of 74i–j, with 74k as quite possibly the most Lively compound during the sequence (pIC50 = https://buyindazole75329.kylieblog.com/31958712/new-step-by-step-map-for-indazole-tablet-uses